Diagnostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin in Detecting Acute Kidney Injury in Asphyxiated Term Neonates

Background: Neonates with Perinatal Asphyxia (PNA) are at higher risk for developing Acute Kidney Injury (AKI). Conventionally, Serum Creatinine (SCr) is used to diagnose AKI but lacks specificity during the first few days of life. Neutrophil Gelatinase-Associated Lipocalin (NGAL) has emerged as a novel biomarker in such situations, while its value our setting yet be validated. The study aimed evaluate role urinary NGAL (uNGAL) level predictive term newborn infants PNA.
 Materials and methods: This prospective observational included 55 full-term neonates PNA from Special Care Neonatal Unit Chittagong Medical College Hospital.The uNGAL was measured by an enzyme-linked immunosorbent assay. Urinary samples were obtained on postnatal day 1(after 6 hours), 3, blood sCr day1, 3 6.
 Results: Among PNA, 20 (36.4%) had AKI. mean ±SD 97.77±17.13 ng/ml compared 25.76±2.19 those without day. An cutoff 28.86 90.0% sensitivity 82.9% predicting same observed lower level, 54.53±14.72 vs 15.17±2.18 no third days. detecting seen 26.43 high validity this Significant differences between measuring one three, whereas difference not significant six.
 Conclusion: showed that might valuable among JCMCTA 2022 ; 33 (1) : 173-177